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The trial of Joaquin "El Chapo" Guzman, who is accused of running the world's biggest drug cartel, is about to begin in the United States with anonymous jurors and high security.

Undated photos from a wanted poster released by the U.S. Marshals Service shows Pedro, left, and his twin brother, Margarito Flores.

The judge ruled that just five news reporters, a fraction of the swarm of media representatives following the trial, will be allowed in the courtroom during jury selection. Given Guzman's current residence at a high-security prison in Manhattan, Federal agents are scrambling to find ways to transport him to the NYC borough without throwing a wrench in the city's traffic flow.

The defendant accused of running the massive Sinaloa drug cartel, observed the first day of jury selection dressed in a navy suit, white shirt with a wide disco-style collar, flashing a smile but otherwise impervious.

There were also questioned in Brooklyn's federal court about their views on the legalization of marijuana, their fluency with Spanish and their feelings toward both law enforcement and cooperating witnesses.

American prosecutors have accused Joaquin Guzman of overseeing a multibillion-dollar drug operation and a ruthless campaign of murders and kidnappings of his rivals.

The judge has ordered the jury to remain anonymous and partially sequestered. His co-defendant Ismael "El Mayo" Zambada remains at large, and violent drug trafficking continues unabated in Mexico.

"I feel very badly about drugs", she said, when Cogan asked about the answer. In the USA, opioid addiction has spiralled into an epidemic.

US prosecutors contend that from 1989 to 2014, the cartel smuggled at least 340,892 pounds (154,626 kg) of cocaine into the United States, as well as heroin, methamphetamine and marijuana, raking in $14 billion. Others are already in jail, housed in special wings to protect them from reprisals.

Last year, there was a record 29,000 murders in Mexico.

Alleged Mexican drug kingpin Joaquin "El Chapo" Guzman somehow always managed to get away.

He was arrested again by Mexican marines in February 2014 but escaped 14 months later before being re-captured in January 2016.

He conducted a secret interview with Sean Penn, who, according to the actor, was unaware he was being surveilled by the Mexican government, and reportedly ended up being the beacon for authorities to ultimately catch up with Guzman.