She kicked off her busy schedule on Friday morning, with a visit to David Sheldrick Wildlife Trust, which is considered the world's most successful orphan elephant rescue and rehabilitation Centre.
The US First Lady will then visit the US Embassy in Nairobi wrapping up the only closed-door engagements on her Kenyan visit.
Trump is advocating for children's welfare as part of her "Be Best" campaign during her first global solo tour as first lady.
She is focusing the trip on her interest in child welfare.
But there were signs of protest, too, as President Trump is not unanimously seen as a friend of Africa.
The first lady looks like she's having the time of her life on her trip to Africa.
Spokesperson for the protestors, Rachael Pope, said the Americans living in Malawi had a "take-home" message for US First Lady. The school is among those in the landlocked country that receive education assistance from the U.S. Agency for International Development, including textbooks.
Her most significant accessories, however, were the Be Best-branded tote bags loaded with school supplies that she gave to teachers at the Chipala Primary School in Lilongwe.
"When people think of Africa, they have these standard narratives", Kim Yi Dionne, a political science professor who specializes in African politics at the University of California, Riverside, told the Times.
During that visit, the former model was snapped cuddling a small child and couldn't stop smiling as she comforted the youngster.
At one point inside the park, Melania Trump laughed as she was pushed back by a playful baby elephant. We are happy today.
President Donald Trump has sought to roll back the USA foreign aid budget, a move that has been criticised by both Republican and Democratic lawmakers.
A small handful of protesters held signs along roads in the capital Lilongwe, with one criticising President Trump's reported use of offensive language to describe some African countries earlier this year. The first lady was quickly encircled by the gleeful children and she smiled and danced some more.