Jose Mourinho launched a strong defence of his use of Rashford last week after the forward was advised to leave Old Trafford by Jamie Carragher.
Full back Antonio Valencia, who is suffering from a persistent knee complaint, has been left in Manchester, with Luke Shaw set to start in his place.
"I don't want to use that before the match as a possible excuse for a not very good performance", he added of the surface, while insisting that he has already made his feelings on it clear to UEFA.
Federer, a 20-times Grand Slam champion, has won tournaments on every playing surface in his sport, and Mourinho spoke of his admiration for the Swiss player's adaptability.
"As an example, we're in Switzerland, home of one of the best ever tennis players, and I am pretty sure the big man [Federer] is not happy to play on such a surface, but he has to play and win. We'll have to do it".
Mourinho, in an upbeat mood after Saturday's second straight win, will be desperate to erase the memory of United's spineless last-16 exit against Sevilla last season, during which frustrated United fans chanted "attack, attack, attack" at their own players.
Last season's reverse did not prevent the Reds from progressing to the knockout rounds, though.
Jose Mourinho's side go into the match having turned their early-season slump around with back-to-back wins in the Premier League, and are now looking to make it three in a row for the first time since April.
"We can't change the pitch", Young Boys manager Gerardo Seoane told a news conference on Tuesday.
"We are improving, we found a certain balance in the team, especially in the competitive attitude", the manager said.
The 20-year-old managed just one Manchester United start, playing a total of 122 Premier League minutes, before being England's match-winner twice during the worldwide break. "When you see the team tomorrow, try to speak about the ones that are going to play and not the ones that aren't", said Mourinho.
United has some momentum going after consecutive wins in the Premier League, and the team will impose its will here by dominating possession, creating a flurry chances and putting three of them away. "They play on artificial turf".