Both sides fielded solid XIs for the match as Luis Enrique oversaw his first game in charge of La Roja after being hired to replace interim boss Fernando Hierro, who managed the team at the 2018 World Cup following the sacking of Julen Lopetegui.
"That focus will come on me and I'm not concerned about it, otherwise I'd make decisions just to boost my own win record", he said when asked about any fear of defeat.
While England had an impressive summer campaign at the World Cup, defying all expectations to reach the semi-finals over in Russian Federation, they did so with a relatively young and inexperienced side.
After struggling last season to convince Jose Mourinho he was worth a place in the team, he has started the current campaign in impressive fashion and his contribution on Saturday before his injury will have impressed Southgate.
The Arsenal forward recovered to put the loose ball into the Spanish net before Makkelie ruled that de Gea had been fouled by Welbeck.
"If anybody wasn't aware of it, then yes [it is a reality check]", Southgate said.
"We have got plenty of other good strikers like Rashford".
In the past Spain were vulnerable whenever they lost possession but against England they seemed more comfortable without the ball and defending with their backs against the wall, as they had to do in the latter stages of the game.
Playing at Leeds before the World Cup was one of my favourite memories of the summer.
"This was a flawless night, the team picked up a huge victory and we saw a very impressive Spain side", said Saul. I still have a lot of faith in the likes of (Liverpool's Dominic) Solanke in particular, who I think has been outstanding at every age level.
Unfortunately, Shaw's night came to an early end after he was stretchered off following a clash of heads with Dani Carvajal. They're still not an incredibly free-flowing team and this friendly has all the hallmarks of being a tight, cagey affair decided by one or two individual moments.
Welbeck's effort was disallowed for what was bizarrely deemed a foul on goalkeeper David De Gea.
"We have to think about the whole match and I think we deserved to win".
"We'll go through some tests".