While Harry and Miranda looked sleek in suit and tie, the Dutchess of Sussex sported a Judith and Charles tuxedo dress.
Michael Jibson, who plays the role in the London production, was standing next to Prince Harry when he launched into his signature song, You'll Be Back.
Their mini-honeymoon over, Prince Harry and Meghan Markle are back to making official public engagements, this time stepping out to see Hamilton at London's Victoria Palace Theatre.
Ah, the perks of the Royal family.
On stage with the cast, Harry broke into mock-song, starting off with "You say." before cutting himself amid cheers and laughter from the cast and audience. Together, they all met with the cast and crew of the show backstage.
Lin-Manuel Miranda, the creator and former star of "Hamilton", was also at Wednesday's show.
Markle is a known for her love of dogs.
Hamilton is an award-winning musical which uses rap, hip hop and R&B to tell the story of Alexander Hamilton, one of the founding Fathers of the United States.
We're excited to see what's next for Meghan's outfit choices after this tailored dress. The evening will raise awareness and funds for Sentebale's work with children and young people affected by HIV in southern Africa.
A pre-royal Meghan Markle shows off her signature style - a figure-hugging LBD - at the SS14 Marchesa fashion show during New York Fashion Week in September 2013.