The European champions equalised when Pepe headed home following a short corner, but Uruguay swept up the field and carved them open once more, with Cavani firing home his second and Portugal unable to respond. Portugal's run for the World Cup came to a screeching halt, thanks to Luis Suarez, 31, Edison Cavani, 31, and the rest of La Celeste.
Elsewhere in the other knockout stage match on Saturday, Portugal will take on Uruguay. I have no words to describe this. Really, really, really happy - look at our fans! "Let's continue to dream".
Portugal, who won EURO 2016 in France, dominated possession but their attack did not have enough bite to break through the Uruguay defence twice.
"Today we committed a mistake that led to the equalizer but we have a very strong team in terms of mindset", Tabarez added, citing the value of his team's "intensity, focus and tactical intuition".
Ronaldo finishes his fourth World Cup campaign with four goals, while Messi notched just the one in what was also his fourth, scoring the opener in Argentina's huge group stage win over Nigeria in Saint Petersburg.
"The distinctive feature of the game was the dedication the players showed on the pitch, and that is the way that we see football", Tabarez said. Ronaldo had an opportunity in the first half to score from a free kick about 30 metres out but could only hit the wall.
"We know that in Portugal, the squares are full, the people are together and rooting for us, and we feel their presence here, so a word to the Portuguese people: We are very sad that we weren't able to make it", Santos said. "We have many young players and it is important to have our captain there". We wanted to win, we fought well, but Uruguay should be congratulated. Uruguay will play France in the last eight in Nizhny Novgorod on Friday.