The Israeli consulate in NY was also singularly unmoved by the Iranian leader's latest bloodcurdling threats.
Iran is to inform the United Nations' nuclear agency that it is beginning the process of increasing its capacity to enrich uranium on Tuesday.
The world should stand up to Washington's bullying behaviour, Iran's foreign minister was quoted as saying on Sunday by state media in a letter to counterparts, as the top diplomat intensifies efforts to save a nuclear deal after a U.S. exit.
European governments have been trying to salvage the nuclear deal ever since the United States announced its withdrawal and said it would reimpose sanctions on foreign companies working in the Islamic republic by November.
As European states and China reiterated their commitment to the nuclear deal, Iran's foreign ministry stated that in spite of Washington's move, Tehran would abide by its obligations under the deal, calling on the global community to stand up against "US law-breaking behavior, bullying and disregard for the rule of law".
Germany, France and Britain are three of the signatories of the 2015 Joint Comprehensive Plan of Action (JCPOA) between world powers and Iran, aimed at keeping Tehran from acquiring nuclear weapons. The JCPOA allows Iran to pursue a peaceful nuclear program for commercial, medical and industrial purposes in line with global non-proliferation standards.
Khamenei and various Iranian political figures have already warned that Iran could leave the agreement if it no longer receives the economic benefits it signed up for.
"Iran calls for our destruction, but it's also seeking nuclear weapons to carry out its genocidal design", he said.
The deal allows Iran to continue 3.67% uranium enrichment, far below the roughly 90% threshold of weapons-grade.
At a press conference with Merkel in the German capital following their meeting, the two leaders agreed that Iranian influence in the region represented a threat to Israel, though the Chancellor reiterated Europe's intention to remain in the deal.
The nuclear accord is "secondary", the Israeli prime minister said in Berlin. The Trump administration has said it will apply severe sanctions on Iran by the end of the year, including penalties against companies that trade with the country. Kamalvandi has said Iran is preparing to expand its uranium enrichment capacity.
Defense Minister Avigdor Liberman also slammed Khamenei's declaration that he had ordered preparations to increase uranium enrichment capacity Monday, according Hebrew media.
The European powers are trying to come up with a package to ring-fence trade with Iran against renewed US financial sanctions to dissuade Tehran from quitting the accord.
Major global companies are already beginning to distance themselves from Iran in fear of U.S. sanctions. We commit, and I commit again, that we will not let that happen, ' he said.