"This is our most significant endeavor ever in Europe and we look forward to showcasing Major League Baseball in one of the world's great cities".
Britain will now join other worldwide venues to have hosted regular-season games, along with Mexico, Japan, Puerto Rico and Australia.
The London Stadium will have a 55,000 capacity for the games but Henry believes Londoners will struggle to secure tickets.
The announcement of MLB's arrival in London comes in the wake of discussions between Rob Manfred, the sport's commissioner, and the Mayor of London, Sadiq Khan, and follows the successful introduction of other U.S. sports into the capital.
Baseball is following in the footsteps of American football, which has regularly held NFL games in London since 2007, and basketball, with NBA matches having become a regular fixture in the capital since 2011. "All the hard work has paid off".
The matches will be held on 29 and 30 June and will be the first Major League Baseball (MLB) games to be staged in Europe. Both will be home games for the Sox. There were significant challenges that had to be overcome. "So we understand there will be a lot of excitement around it", said Yankees manager Aaron Boone on Sunday. This series will surely be the most significant worldwide event to date for Major League ball. "Bringing these storied teams together for British fans - who have such a profound appreciation for sports at the highest level - only adds to the unique allure of one of the world's greatest sporting rivalries". Every year we fight for the division championship.