Controlling all six sessions of the Test, Pakistan are now the strong favourites to triumph and take a 1-0 lead in this two-match series.
Set a target of just 64 on the fourth morning, Pakistan finished on 66 for one before lunch to go 1-0 up in this two-match series ahead of next week's second Test at Headingley.
Imam-ul-Haq was 18 not out and Haris Sohail, who hit the winning boundary off Dominic Bess, 39 not out.
But, in truth the damage had always been done by a pair of top-order slumps that saw England, so often dominant in early-season home conditions, dismissed for 184 in their first innings before declining to 110 for six second time around.
This was England's seventh loss in 10 Tests as their first match under new national selector Ed Smith ended in a resounding reverse.
The second and final test begins Friday at Leeds, with England potentially already needing to rejig its team after rolling over meekly at the home of cricket to extend its winless run in tests to eight matches.
But on the resumption, fanciful hopes of an improbable victory faded fast as England lost their last four wickets for seven in 25 balls to be bowled out for 242.
Mahmood, who is now Pakistan's Bowling Coach, retired from global cricket in 2007, having played 21 Test matches and 143 One-Day Internationals for his country in a career spanning eleven years. "We were outperformed in all three disciplines".
In a reversal of the expected order of things, England were disastrous in the field in this Test, chances missed and catches put down with the sort of tragicomic regularity usually so championed by Pakistan - as it was their opponents could scarcely have looked sharper.
"We have a very inexperienced team but we are very confident in our players".
Buttler, though, was out in the second over of the day, having added just one run to his overnight score. "They did a great job for us", said the wicket-keeper.
"I think we did some really good work leading into this game". Mark Wood had no answer to Amir's wiles when the new ball was taken midway through the next over - he grazed Amir through to Sarfraz for 4.
Abbas followed the example of Amir to dismiss Stuart Broad for a duck in similar fashion, Sarfraz gathering another edge after an unconvincing prod.
It was the latest memorable Lord's incident for Amir, who took six wickets in a Test innings at MCC's headquarters in 2010 - the same match where his involvement in a spot-fixing scandal led to a jail sentence and a five-year ban from cricket.
Cook, playing in a record-equalling 153rd consecutive Test, was bowled by an excellent delivery from Mohammad Amir to end an innings lasting over three hours.