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Russian Federation and Syria have invited a probe into the alleged chemical attack on the rebel-held town of Douma after United States president Donald Trump threatened that there would be a "big price to pay".

Iran, a key ally of Assad, condemned the airstrikes, which it said killed four Iranians, including a colonel and a member of the Revolutionary Guard's aerospace force.

The supposed poison gas attack killed at least 80, leaving men, women and children foaming at the mouth and struggling to breathe in the rebel-held town of Douma, a suburb of Damascus.

A Syrian airbase was hit with a missile attack early on Monday, the country's official news agency reported, a day after U.S. President Donald Trump warned of a "big price to pay" in response to reports of a chemical attack outside the nation's capital. In a statement, it said a fact-finding mission was gathering information from all available sources to establish whether chemical weapons were used. The US Department of Defence, however, denied government forces had launched any chemical attack.

"Many dead, including women and children, in mindless CHEMICAL attack in Syria", tweeted Trump. "Nothing is off the table", he warned.

It was less than a week ago that Trump announced during a rally in OH that he planned to get USA troops out of Syria "very soon".

"Everybody's going to pay a price". He tweeted on Sunday there would be a "big price to pay" and said Russian Federation, its president, Vladimir Putin, and Iran were responsible for enabling "Animal Assad".

But Russia blocked several similar resolutions in the past, and Nebenzya hinted that the latest one - which he called "unacceptable" - would meet the same fate. "And they need to look very carefully at the position they have taken", she said.

According to The Atlantic, The White Helmets, a voluntary aide group, pinned the blame for the assault, which claimed more than 40 civilian lives, on the Syrian President Bashar al-Assad's regime.

Israeli opposition lawmaker Yair Lapid told Army Radio: "Israel will not accept an Iranian military presence in Syria and will not accept Iran's creeping entrenchment in Syria and this has costs".

The ministry says Syria shot down five out of the eight missiles that targeted the base. The TV gave no further details.

A military spokeswoman for Israel, which on occasions in the past has struck targets inside Syria, declined to comment on explosions at T4. Amos Yadlin, a former Israeli fighter pilot and ex-head of Israeli military intelligence, stopped short of saying Israel was responsible for the airstrike. "Thus I believe it was Israel that carried out the attack". "Israel is determined not to let them do that".

"The Syrian Air Defense Force has destroyed a few missiles, which attacked the T-4 air base".

At least 14 people have died following missile strikes on a Syrian military air base in Tayfur, near the city of Homs.

AP quoted SANA saying it was "likely to be an American aggression" though USA officials told the organization no American military action had been taken. The use of chemical weapons in April 2017 provoked a USA missile strike, the first direct American hit on Bashar al-Assad's regime since the conflict in Syria began in March 2011.