Ohtani didn't fare as well against the Red Sox, who rank first in the Majors with an.831 OPS and are off to a 14-2 start.
"[The blister] had an effect on the overall command of all his pitches", Mike Scioscia said.
Following the 23-year-old's stellar start to the season with both bat and ball in a rookie campaign that has already seen him compared to Hall of Famer Babe Ruth, backing for Ohtani in his homeland has increased with each passing week.
Boston lefty David Price (2-1) struck out six and allowed one run and four hits in five innings for the Red Sox, who lead the American League East.
Through two starts, Ohtani would compile 18 strikeouts to just two walks.
"I tried to pitch today but with the high intensity of the game, it didn't hold up too well".
The 25-year-old had his first two three-homer games in 2016 and once again showed that he is among the most risky players in the majors.
One inning after Ohtani left, the Angels announced the right-hander had developed a blister during the second inning.
Angels pitchers tend to break frequently (see: JC Ramirez, Andrew Heaney, Matt Shoemaker, etc.), so we should all probably be a little concerned.
Red Sox: Betts was in Boston's lineup for the first time since Saturday, when he injured his foot in a home plate collision. This time, he settled in against Angels reliever Luke Bard.
Martinez explained that Austin broke an unwritten rule that merited retaliation from the Red Sox.
Angels: RHP Matt Shoemaker said his injured right forearm feels considerably better after some rest, but he still hasn't been cleared to throw. He has won five straight decisions since last September. "I wanted to go back out but they just told me we should end the night right there", Ohtani said through a translator. The left-hander hasn't yielded more than two runs in a start this year.