Boasting a 12-point lead at the top of the table, Barca now turn their attention to the Champions League quarter-final first leg at home to Italian giants Roma on Wednesday.
Messi began Barca's game away to Sevilla on the subs' bench due to a groin injury and it was not until around half an hour from the end that coach Ernesto Valverde chose to risk him.
The hosts' strong first-half was rewarded in the 36th-minute through Franco Vazquez's goal, and Luis Muriel doubled their advantage five minutes after the interval.
"He is a player that is decisive every time he touches the ball".
But they were made to rue wasted chances from that duo and Jesus Navas as Barca showed why they are the top side in Spain this season.
They would have been deserving winners here and, in truth, could have been out of sight had Muriel and Vazquez finished any number of risky breaks in the second half.
"Liga games are like this when your rival takes the game to you. We want to compete until the end of the season", Valverde told reporters.
With Umiti's buyout clause said to be a rather miserly €60m, the vultures have become to circle and it has been reported that Manchester United are ready to activate his buyout clause and treble his wages.
Valverde concedes his side played a risky game in the second half, adding: "The first half was fairly balanced, even though they had some unsafe counter-attacks".
"This will be great for the spirit of the team because we know how important the game was to keep that run without losing going".
Another chance saw Suarez hit the post from a tight angle, but Sevilla still posed more of an attacking threat - Muriel and substitute Miguel Layun both wasting good openings.
"You're a bit angry of course and nervous (with Barcelona's comeback), but I'm also proud because the team played with confidence".
Sevilla coach Vincenzo Montella, whose side are in action against Bayern Munich in the Champions League on Tuesday, was left to lament a lack of efficiency in the final third.
The first two games of the weekend ended in 1-1 draws between Girona and Levante and Athletic Club Bilbao and Celta Vigo.