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The tests did not show whether taking the male birth control drug actually reduced sperm production to levels that would prevent pregnancy, but contraceptive effectiveness will be tested in another trial beginning in April, Fox News reported.

The brand-new innovative contraceptive pill for men contains DMAU (dimethandrolone undecanoate) and is made of a mixture of hormones, such as progestin and testosterone, and works similarly to the contraceptive pills for women.

"And 60 to 80 percent of men surveyed in such studies say if there was a reversible contraceptive available, they would be very interested in using it". Overall, 100 men between the ages 18 and 50 were enrolled in the trial and 82 completed all parts of the study.

Dr Page said longer term studies are now underway to confirm that when taken every day, DMAU blocks sperm production.

"Despite having low levels of circulating testosterone, very few subjects reported symptoms consistent with testosterone deficiency or excess", says Page. For example, oral testosterone drugs usually leave the body quickly - meaning that men would have to take the pills twice a day for the drug to be effective, Page said.

"Individuals on all the doses had remarkably low testosterone levels", Page said.


"These results are a big step forward in the development of a male pill", she told MedPage Today.

Plus the pills must be taken with food or they won't work. DMAU must be taken with food to be effective, Page noted. Maybe the study that begins in April will present us encouraging findings as well as the one presented at ENDO 2018, the Endocrine Society's 100th annual meeting in Chicago, on Sunday. A team of Australian researchers has been working to develop a novel non-hormonal form of male contraceptive that blocks sperm transport instead of disrupting sperm maturation.

"The men experienced no hot flashes and no mood changes, and no problems with sexual function compared with the placebo group", Paige said.

However, many men who took the pill did experience weight gain - about 3 to 8 lbs., on average - during the study, and they saw a drop in their levels of "good" cholesterol. DMAU "does have the promise of blocking sperm production", Courgi said.

The trials showed the pill can be given safely for more than one dose, but did not yet test for its success as contraception.

As it was acknowledged that further studies are needed to gauge whether the new contraceptive for men can truly be effective in actual use, the researchers hope to determine in the future whether the drug affects sperm count for a span of three months.


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