Not only did Salah net four times himself to take a commanding lead in the race for the league's golden boot by moving four clear of Harry Kane on 28 goals, he also set up Roberto Firmino for Liverpool's third.
There was no respite for Watford at a snowy Anfield as the clinical Salah smashed in his fourth goal in the 85th minute - from his fourth shot on target.
Notably, the 47-year-old Spanish tactician was in-charge of Osasuna when Messi's hat-trick helped Barcelona complete a 7-0 thrashing in the 2013/14 La Liga season.
"At the end you need to play against the best to win this trophy", Germany worldwide Gundogan said to City's website.
"I'll only reveal it at the end of the season". They are different players. We have very good chemistry here at Liverpool.
"They are very agile team, the players move a lot around the pitch". They are both so good in their own right. "We have beaten them for a start".
There were only four matches played on Saturday, with the remaining six games postponed because of some clubs' involvement in the FA Cup quarter-finals.
Salah is making waves across Europe as one of the hottest players on the continent. "That is what happened with Salah", he added. "He (Messi) has been doing what he's been doing for what feels like 20 years or so. the last player I know who had the same influence on a team performance was Diego Maradona".
Miguel Britos has confessed that he struggled to contain Mohamed Salah in Saturday's heavy defeat to Liverpool and now wants to forget all about the game. "Sometimes you just can't do anything", Gracia explained.
"There is no one who speaks about that because the front three, or the players up front, score the goals and we win". They have a high pressing level, higher level than Barcelona.
Firmino's 23rd of the season marked the best goalscoring campaign of his career, beating the 22 he managed in 2013-14, and while Mane did not get on the scoresheet it was another performance which showed he is starting to rediscover the form of past year.