While the losses are significant, the results still are positive for Uber with revenue rising and losses falling in three of four quarters in 2017, said Rohit Kulkarni, managing director of SharesPost, a research group focused on privately held companies.
The quarterly figures come less than a week after Uber settled what could have been a very expensive lawsuit brought by Waymo.
He also landed in the midst of a court battle that pitted Uber against a Google spinoff alleging that the ride-hailing service had conspired to steal its self-driving auto technology while Kalanick was running things.
The legal battle between Google's Waymo and ride-hailing company Uber aroused when Waymo put allegations of stealing their self-driving technology secrets by Uber in order to first introduce the self-driving technology developed cars in the market to the masses.
Gross revenue for the year rose 85 per cent over 2016, to $US37 billion. Despite a turbulent year for the company, it still managed to earn sales of $7.5 billion, although this was tempered by a substantial loss of $4.5 billion, an unprecedented number.
The latest financial report shows the company continues to increase its revenue while making progress on cutting its loss.
The ride-hailing firm ended 2017 with about $6 billion in cash, including $1.4 billion money set aside for potential insurance claims.
CEO Travis Kalanick was ousted in June and replaced by Khosrowshahi in August.
Waymo filed its lawsuit almost a year ago, adding to Uber's woes with allegations of a bold hi-tech heist orchestrated by its former CEO, Travis Kalanick, and a former Google engineer.
Waymo had alleged that Anthony Levandowski, one of its former employees, had taken Waymo's trade secrets after leaving the company to found his own autonomous truck company, Otto.
A source familiar with the confidential deal said Uber agreed to a financial settlement giving the Alphabet unit 0.34% of Uber shares - which would be some US$244 million based on Uber's valuation of US$72 billion. Mr Khosrowshahi detailed them on a conference call with investors Tuesday, and the company made some results public.