Maitland-Niles played at left-back on Wednesday in the 2-2 draw at Chelsea, and Wenger said the 20-year-old may play in his preferred midfield position at the City Ground.
The third round of the competition marks the introduction of England's top teams to the competition.
Warburton departed alongside Director of Football Frank McParland and Assistant Manager David Weir after just nine months in charge, despite avoiding relegation last season and guiding Forest to 14th this season.
"I will rotate a little bit because we have also come out of a very high-loaded period", he said.
Aaron Ramsey remains out with a hamstring injury and Granit Xhaka has been ruled out with a groin problem so Jack Wilshere is nearly certainly going to be rested this weekend after starting our last six games.
Forest will check on the fitness of Daryl Murphy.
Nottingham Forest most recently played to a scoreless draw with Leeds United on January 1.
Granit Xhaka, Aaron Ramsey, Sead Kolasinac, Olivier Giroud and Nacho Monreal are all injured.
I am concerned about Arsenal here.
"Alexis Sanchez, Mesut Ozil, Jack Wilshere and Alexandre Lacazette won't play but the real concern is that defence".
Wenger has been hit with a three-match suspension and a £40,000 fine for the comments made after Arsenal's 1-1 draw with West Brom on New Year's Eve, in which Mike Dean awarded a controversial penalty for a supposed handball from Calum Chambers.