To start the game, the Packers go with a surprise on-side kick and they recover it to steel a possession.
Coach Jim Caldwell is expected to coach his last game for Detroit on Sunday, sources said.
The Lions get the ball back after an interception.
The Lions' Matt Prater responded with a 28-yard field goal of his own to knot the count at 3-3 with 3:03 to go in the first period.
Stafford threw a go-ahead, 54-yard pass to Kenny Golladay.
Matthew Stafford completed 20-of-29 passes for 324 yards and three touchdowns.
The Packers were behind 20-3 at halftime and at one point trailed 27-3.
Brett Hundley was a disappointing 14-of-24 for 174 yards. Detroit, meanwhile, was close to full strength in what could be Jim Caldwell's final game as head coach. Minnesota Vikings free safety Harrison Smith deflects a pass intended for Detroit Lions tight end Darren Fells (87) during the first half of an NFL football game, Thursday, Nov. 23, 2017, in Detroit. He caught a 2-point conversion pass after Ameer Abdullah, who had just run for a TD, took a direct snap and pitched it to Tate, who easily connected with Stafford in the end zone to put Detroit up 35-11 midway through the fourth quarter.
This marked the second meeting this season between the two squads. CB Davon House had a shoulder injury and Williams was evaluated for a concussion late in the game.
Lions: Stafford, with a lot of tape covering his right cleat, stayed in the game after hurting his right ankle on his second touchdown when DT Tom Johnson fell on him.